Spectrophotometric study of the oxidation of fosfomycin by potassium permanganate in aqueous perchloric acid medium _ a kinetic and mechanistic approach
Keywords:
Fosfomycin, Permanganate, Kinetics and mechanismAbstract
The kinetics of oxidation of fosfomycin (FOS) by potassium permanganate in perchloric acid medium has been studied spectrophotometrically at 25 oC and at constant ionic strength of 3.60 mol dm-3. The stoichiometry of the reaction is determined and found that one mole of permanganate requires one mole of FOS (1:1). The reaction shows first-order dependence in permanganate and apparently less than unit order in both fosfomycin and acid concentrations. The identified oxidation products are Mn2+, formyl phosphonic acid and acetic acid. Reaction rate increases with increase in ionic strength. The increase in the acetic acid content in the reaction medium decreased the rate of the reaction. Based on the experimental results a mechanism involving complex formation between MnO4- and substrate has been proposed. The reaction constants involved in the different steps of mechanism are calculated and activation parameters with respect to thermodynamic quantities are computed and discussed. From this spectroscopic investigation we proposed suitable scheme of the experiment.
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