Synthesis and Characterisation of a Hydrophilic Support for Solid Phase Organic Reactions
Keywords:
Solid phase synthesis, GDMA-4VP resin, suspension polymerizationAbstract
Glycerol dimethacrylate cross-linked 4-vinyl pyridine (GDMA-4-VP) support with optimum hydrophobic-hydrophilic balance has been introduced as a new class of polymer support in manual solid phase organic synthesis. The synthesis of GDMA-4-VP resin is based on the crosslinking of GDMA with 4-VP (in various cross linking densities) using free radical polymerization, affording a polymer containing secondary hydroxyl groups in great yield and purity. Benzoyl peroxide was used as initiator for the synthesis of polymer either via bulk polymerization or via suspension polymerization in polyvinyl alcohol, the latter yielding a beaded resin. Characterization was done by SEM and FT-IR spectroscopic techniques. The resin was found to undergo good swelling in various solvents, polar and non- polar. The synthetic utility of GDMA-4-VP resin was demonstrated by preparing biologically active Angiotensin II. The purity of the peptide was checked by HPLC.
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