Determination of the optimal conditions to produce lovastatin compound from the fungus (Penicillium digitatum)
Keywords:
Fermentation, extraction, lovastatinAbstract
This study was done to determine an ability of the fungus (Penicillium digitatum) to produce lovastatin compound after do experiments by using method of Solid State Fermentation (SSF). The fermentation method was carried out within presence of a mixture of three organic substrates (wheat bran, oat bran, soybeans), carbon and nitrogen sources (potato peels powder, yeast extract, milk powder) at different environmental conditions (temperature degrees, acidity degrees, concentration of spore suspension, and period time). After that, lovastatin compound was extracted by using ethanol 95%. This study showed that the highest concentration of lovastatin reached 155.93 mg/g of dry substrate after 10 days from fermentation in temperature degree 300C, pH=6, and concentration of spore suspension 108 spore/ml.
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